An ER clamp for endosome fission
نویسندگان
چکیده
منابع مشابه
An ER clamp for endosome fission.
Endosomes are known to undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. A recent paper (Rowland et al, 2014) shows that contact sites between endosomes and the endoplasmic reticulum (ER) define the position and timing for fission. This uncovers an unanticipated role for the ER in controlling endos...
متن کاملER Contact Sites Define the Position and Timing of Endosome Fission
Endocytic cargo and Rab GTPases are segregated to distinct domains of an endosome. These domains maintain their identity until they undergo fission to traffic cargo. It is not fully understood how segregation of cargo or Rab proteins is maintained along the continuous endosomal membrane or what machinery is required for fission. Endosomes form contact sites with the endoplasmic reticulum (ER) t...
متن کاملER-endosome contact sites in endosome positioning and protrusion outgrowth.
The endoplasmic reticulum (ER) makes abundant contacts with endosomes, and the numbers of contact sites increase as endosomes mature. It is already clear that such contact sites have diverse compositions and functions, but in this mini-review we will focus on two particular types of ER-endosome contact sites that regulate endosome positioning. Formation of ER-endosome contact sites that contain...
متن کاملOrganelle Dynamics: ER Embraces Mitochondria for Fission
The endoplasmic reticulum and mitochondria are engaged in an intimate relationship: they establish extensive contacts, exchange lipids and calcium, and coordinate their activities in cell life and death. Recent research has revealed a new role for the endoplasmic reticulum in promoting mitochondrial division.
متن کاملMitochondrial Fission: Regulation and ER Connection
Fission and fusion of mitochondrial tubules are the main processes determining mitochondrial shape and size in cells. As more evidence is found for the involvement of mitochondrial morphology in human pathology, it is important to elucidate the mechanisms of mitochondrial fission and fusion. Mitochondrial morphology is highly sensitive to changing environmental conditions, indicating the involv...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2014
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.201490707